Biostatistician Salary in Chicago, IL: 2026
Biostatistician salary data for Chicago, IL, adjusted for local cost of living. Entry-level to senior pay ranges, take-home pay calculator, and local job market insights.
The estimated median Biostatistician salary in Chicago, IL is $113,046 per year ($9,421/month, $54/hr). This modeled estimate scales Salario's national benchmark (calibrated to the BLS OEWS May 2025 national median) by the local cost of living index of 107, which is 7% above the national average.
All four figures are Salario estimates (national benchmark scaled by Chicago's cost-of-living index); BLS does not publish a metro median for this title here.
Biostatistician Take-Home Pay in Chicago
Tax Breakdown (Median Salary)
| Gross Annual | $113,046 |
| Federal Tax | -$16,040 |
| State Tax (5.0% eff.) | -$5,596 |
| FICA (SS + Medicare) | -$8,648 |
| Annual Take-Home | $82,762 |
| Monthly Take-Home | $6,897 |
Living Cost Comparison
Biostatistician Requirements
Key Skills
Chicago Job Market Overview
Chicago, Illinois has a population of 2,696,555 and an unemployment rate of 4.2%. The top industries are Finance, Technology, Healthcare. The local job growth rate is 1.5%, and the average commute time is 35minutes. These local figures come from Salario's city dataset; verify current values with BLS Local Area Unemployment Statistics and Census QuickFacts.
Related Science Salaries in Chicago
Salary Percentile Breakdown: Biostatistician in Chicago
Based on Salario's cost-of-living-adjusted salary tiers for Biostatistician in Chicago, IL, here is an estimated percentile breakdown:
| Percentile | Annual Salary | Hourly Equivalent | Career Stage |
|---|---|---|---|
| 10th (lowest) | $72,653 | $35/hr | Entry-level, < 1 yr exp. |
| 25th | $92,850 | $45/hr | Junior, 1-3 yrs exp. |
| 50th (median) | $113,046 | $54/hr | Mid-career, 2-4 years |
| 75th | $164,994 | $79/hr | Senior, 5-10 yrs exp. |
| 90th (top) | $205,333 | $99/hr | Lead/Principal, 10+ yrs |
Percentiles are approximations, not measured local percentiles: P10, P50, P75, and P90 map to Salario's entry, median, senior, and top salary tiers scaled by the local cost-of-living index, and P25 is interpolated halfway between entry and median. Top earners (P90) typically include managers, specialists with rare skills, or those at high-paying employers in Chicago's Finance sector.
5-Year Salary Trajectory
Salario's national dataset models approximately 18.0% salary growth for Biostatisticians over the past 5 years. That national assumption is applied to the Chicago estimate below; it is not a measured local trend, and it should be compared with cumulative CPI inflation before treating it as a real-terms gain:
Year-over-year, an average Biostatistician can expect a 14.6% annual increase moving from entry to senior level over 6 years in Chicago. Negotiation, certifications (PStat, ASA Certification), and changing employers strategically can accelerate this trajectory.
Chicago vs National Average
The national median Biostatistician salary is $105,650 (BLS OEWS May 2025, Statisticians). In Chicago, the cost-of-living-adjusted median of $113,046 is 7.0% above the national figure. This reflects Chicago's cost of living index of 107 (higher than the national average of 100).
For Biostatisticians, this means: rent typically consumes 25.4% of take-home pay (households spending >30% are considered affordable), and a median home in Chicago costs about 3.9× annual take-home. Homeownership is relatively attainable on this salary in Chicago.
Industry Context: Finance in Chicago
Chicago's economy is anchored by Finance, Technology, Healthcare, with 2,696,555 residents and an unemployment rate of 4.2% in Salario's city dataset. Pay for Biostatisticians can differ by sector, so compare Finance employers with other local employers. The local job growth rate in Salario's city dataset is 1.5%, and Salario's job dataset lists a 30.0% growth outlook for Biostatistician roles; check the BLS Occupational Outlook Handbook for the official 2024-2034 projection for the closest matching occupation.
Methodology & Data Sources
How we calculate Biostatistician salaries in Chicago, IL:
- Base salary model starts with Salario occupation data and public wage references, including BLS OEWS and O*NET when a direct or related occupational crosswalk is available (the national median is calibrated to the BLS OEWS May 2025 median for Statisticians). For niche titles, we do not treat a broader SOC family as an exact job-title wage.
- Cost-of-living adjustment applied using the Chicago index of 107 relative to the national baseline of 100, with local rent, home price, unemployment, and tax inputs stored separately in Salario's city dataset.
- Percentile distribution (P10-P90) estimated from the entry, median, senior, and top compensation tiers in the Salario salary model rather than claimed as exact employer payroll data.
- Take-home pay calculated using 2026 federal tax brackets (10%-37%), IL 2026 state income tax brackets after the standard deduction (top rate 5.0%), and FICA (Social Security 6.2% + Medicare 1.45%).
- Tax brackets and standard deduction ($16,100 single filer for tax year 2026) sourced from IRS Revenue Procedure 2025-32 and updated annually.
Authoritative data sources:
- BLS Occupational Employment and Wage Statistics, national and metro-area salary data
- O*NET OnLine, occupation tasks, alternate job titles, skills, and SOC crosswalks
- BLS Occupational Outlook Handbook, occupation outlook where a matching profile is available
- BLS Consumer Price Index (CPI-U), regional inflation data (CPI measures price changes, not city-to-city price levels)
- U.S. Census Bureau, Chicago QuickFacts, population and demographic data
- IRS Revenue Procedure 2025-32 summary, 2026 federal tax brackets and standard deductions
- BLS Local Area Unemployment Statistics, official local unemployment rates to verify the Chicago figure above
Last reviewed: 2026. Salario's salary dataset is refreshed periodically, not automatically; check the linked BLS releases for the latest official data. Biostatistician salaries can vary significantly based on employer, sector (Finance vs others in Chicago), specific skill set (SAS, R, Clinical Trials), and individual negotiation. Always verify current compensation through multiple sources before making career decisions.
Frequently Asked Questions
What is the average Biostatistician salary in Chicago, IL?
How much does a Biostatistician take home in Chicago after taxes?
Is Chicago a good city for Biostatisticians?
What skills are needed for a Biostatistician in Chicago?
How does Biostatistician salary in Chicago compare to the national average?
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Frequently Asked Questions
What is the average Biostatistician salary in Chicago, IL?
Salario estimates the median Biostatistician salary in Chicago, IL at $113,046 per year for 2026. This is a modeled figure: Salario's national Biostatistician benchmark scaled by the local cost of living index of 107, not a measured local wage survey. The modeled entry-level estimate is around $72,653, and the senior estimate is $164,994 or more.
How much does a Biostatistician take home in Chicago after taxes?
A Biostatistician earning the median salary of $113,046 in Chicago, IL takes home approximately $82,762 per year ($6,897/month) after federal, state, and local taxes. The effective tax rate is 26.8%.
Is Chicago a good city for Biostatisticians?
Chicago, IL has a cost of living index of 107 (above national average). Biostatisticians here earn above the city median. The local unemployment rate is 4.2% and top industries include Finance, Technology, Healthcare.
What skills are needed for a Biostatistician in Chicago?
Key skills for Biostatisticians include SAS, R, Clinical Trials, Survival Analysis, Epidemiology. Typical education requirement is Master's Degree. Valuable certifications include PStat, ASA Certification.
How does Biostatistician salary in Chicago compare to the national average?
Salario's national median benchmark for Biostatistician is $105,650 (calibrated to the BLS OEWS May 2025 national median). In Chicago, the cost-of-living-adjusted estimate is $113,046, which is 7.0% higher than the national average, reflecting the local cost of living.