Physician Assistant Salary in San Francisco, CA — 2026
Physician Assistant salary data for San Francisco, CA — adjusted for local cost of living. Entry-level to senior pay ranges, take-home pay calculator, and local job market insights.
The median Physician Assistant salary in San Francisco, CA is $221,400 per year ($18,450/month, $106/hr). This reflects the local cost of living index of 180, which is 80% above the national average.
Also known as: PA, Physician Associate, Medical Assistant. Salary data on this page applies to all of these job titles in San Francisco, CA.
Physician Assistant Take-Home Pay in San Francisco
Tax Breakdown (Median Salary)
| Gross Annual | $221,400 |
| Federal Tax | -$42,152 |
| State Tax (9.3%) | -$20,590 |
| FICA (SS + Medicare) | -$14,649 |
| Annual Take-Home | $144,009 |
| Monthly Take-Home | $12,001 |
Living Cost Comparison
Physician Assistant Requirements
Key Skills
Physician Assistant salary search terms in San Francisco
People comparing Physician Assistant pay in San Francisco, CA may use related job-title wording. Salario keeps the main estimate tied to the Physician Assistant role, then treats the terms below as comparison phrases that should be checked for licensing, employer type, seniority, and role scope.
| Comparison point | How to use it |
|---|---|
| Primary local answer | $221,400 median salary, $165,600-$282,600 modeled range, and $144,009 estimated take-home pay in San Francisco. |
| Title variants | PA, Physician Associate, Medical Assistant can point to similar searches, but some variants may represent a narrower specialty or a higher/lower seniority band. |
| Offer comparison | Compare base salary, hourly equivalent, take-home pay, certifications, local cost of living, and whether the job is employee, contractor, public-sector, commission-heavy, or management-level. |
San Francisco Job Market Overview
San Francisco, California has a population of 873,965 and an unemployment rate of 3.2%. The top industries are Technology, Finance, Healthcare. The local job growth rate is 2.5%, and the average commute time is 34 minutes.
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Physician Assistant Salary in Nearby California Cities
Salary Percentile Breakdown — Physician Assistant in San Francisco
Based on the cost-of-living-adjusted distribution for Physician Assistant in San Francisco, CA, here's how earnings break down across the workforce:
| Percentile | Annual Salary | Hourly Equivalent | Career Stage |
|---|---|---|---|
| 10th (lowest) | $165,600 | $80/hr | Entry-level, < 1 yr exp. |
| 25th | $193,500 | $93/hr | Junior, 1-3 yrs exp. |
| 50th (median) | $221,400 | $106/hr | Mid-career, 0-2 years |
| 75th | $282,600 | $136/hr | Senior, 5-10 yrs exp. |
| 90th (top) | $336,600 | $162/hr | Lead/Principal, 10+ yrs |
Percentiles estimated using a log-normal salary distribution model calibrated to Physician Assistant compensation data. Top earners (P90) typically include managers, specialists with rare skills, or those at high-paying employers in San Francisco's Technology sector.
5-Year Salary Trajectory
Physician Assistant salaries in San Francisco have grown approximately 15.0% over the past 5 years, outpacing local CPI inflation in many cases. Here's the historical and projected trajectory:
Year-over-year, an average Physician Assistant can expect a 14.3% annual increase moving from entry to senior level over 4 years in San Francisco. Negotiation, certifications (PANCE, NCCPA Certification), and changing employers strategically can accelerate this trajectory.
San Francisco vs National Average
The national median Physician Assistant salary is $123,000. In San Francisco, the cost-of-living-adjusted median of $221,400 is 80.0% above the national figure. This reflects San Francisco's cost of living index of 180 (higher than the national average of 100).
For Physician Assistants, this means: rent typically consumes 28.3% of take-home pay (households spending >30% are considered affordable), and a median home in San Francisco costs about 8.7× annual take-home. Homeownership in San Francisco on this salary is challenging — most experts recommend keeping home costs to 3-4× income.
Industry Context: Technology in San Francisco
San Francisco's economy is anchored by Technology, Finance, Healthcare, with 873,965 residents and 3.2% unemployment as of 2026. Physician Assistants working in the Technology sector typically earn at or above the local median due to industry-specific demand. The state's overall job growth rate is 2.5%, and Physician Assistant occupations specifically are projected to grow 28.0% nationally through 2034 (BLS Occupational Outlook Handbook).
Methodology & Data Sources
How we calculate Physician Assistant salaries in San Francisco, CA:
- Base salary model starts with Salario occupation data and public wage references, including BLS OEWS and O*NET when a direct or related occupational crosswalk is available. For niche titles, we do not treat a broader SOC family as an exact job-title wage.
- Cost-of-living adjustment applied using the San Francisco index of 180 relative to the national baseline of 100, with local rent, home price, unemployment, and tax inputs checked separately.
- Percentile distribution (P10-P90) estimated from the entry, median, senior, and top compensation tiers in the Salario salary model rather than claimed as exact employer payroll data.
- Take-home pay calculated using 2026 federal tax brackets (10%-37%), CA state income tax of 9.3%, and FICA (Social Security 6.2% + Medicare 1.45%).
- Tax brackets and standard deduction ($16,100 single filer for tax year 2026) sourced from IRS Revenue Procedure 2025-32 and updated annually.
Authoritative data sources:
- BLS Occupational Employment and Wage Statistics — national and metro-area salary data
- O*NET OnLine — occupation tasks, alternate job titles, skills, and SOC crosswalks
- BLS Occupational Outlook Handbook — occupation outlook where a matching profile is available
- BLS Consumer Price Index (CPI-U) — regional inflation and cost-of-living data
- U.S. Census Bureau — San Francisco QuickFacts — population and demographic data
- IRS Revenue Procedure 2025-32 summary — 2026 federal tax brackets and standard deductions
- BLS Local Area Unemployment Statistics — San Francisco unemployment rate
Last reviewed: 2026. Salary data updated annually as new BLS releases become available. Physician Assistant salaries can vary significantly based on employer, sector (Technology vs others in San Francisco), specific skill set (Clinical Examination, Diagnosis, Procedure Assistance), and individual negotiation. Always verify current compensation through multiple sources before making career decisions.
Frequently Asked Questions
What is the average Physician Assistant salary in San Francisco, CA?
How much does a Physician Assistant take home in San Francisco after taxes?
Is San Francisco a good city for Physician Assistants?
What skills are needed for a Physician Assistant in San Francisco?
How does Physician Assistant salary in San Francisco compare to the national average?
What job titles are similar to Physician Assistant in San Francisco?
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- Amortio: Home Affordability — what home you can buy on this income
Frequently Asked Questions
What is the average Physician Assistant salary in San Francisco, CA?
The median Physician Assistant salary in San Francisco, CA is $221,400 per year as of 2026. This is adjusted for the local cost of living index of 180. Entry-level Physician Assistants earn around $165,600, while senior-level professionals can earn $282,600 or more.
How much does a Physician Assistant take home in San Francisco after taxes?
A Physician Assistant earning the median salary of $221,400 in San Francisco, CA takes home approximately $144,009 per year ($12,001/month) after federal, state, and local taxes. The effective tax rate is 35.0%.
Is San Francisco a good city for Physician Assistants?
San Francisco, CA has a cost of living index of 180 (above national average). Physician Assistants here earn above the city median. The local unemployment rate is 3.2% and top industries include Technology, Finance, Healthcare.
What skills are needed for a Physician Assistant in San Francisco?
Key skills for Physician Assistants include Clinical Examination, Diagnosis, Procedure Assistance, EHR, Patient Education. Typical education requirement is Master's Degree. Valuable certifications include PANCE, NCCPA Certification.
How does Physician Assistant salary in San Francisco compare to the national average?
The national median Physician Assistant salary is $123,000. In San Francisco, the adjusted salary is $221,400, which is 80.0% higher than the national average, reflecting the local cost of living.
What job titles are similar to Physician Assistant in San Francisco?
Related search terms for Physician Assistant in San Francisco, CA include PA, Physician Associate, Medical Assistant. Use them as comparison terms, not always exact matches: licensing, employer type, seniority, public-sector rules, and whether the role is W-2, contractor, clinical, technical, management, or sales-focused can change the salary range.