Physician Assistant Salary in San Francisco, CA: 2026
Physician Assistant salary data for San Francisco, CA, adjusted for local cost of living. Entry-level to senior pay ranges, take-home pay calculator, and local job market insights.
The median Physician Assistant salary in San Francisco, CA is $184,380 per year ($15,365/month, $88.64/hr). That is the BLS OEWS May 2025 median annual wage for Physician Assistants in the San Francisco-Oakland-Fremont, CA metropolitan area, which covers San Francisco. Salario's cost-of-living model (index 180) would have estimated $244,584; the entry, senior and top tiers below are Salario estimates rescaled to the BLS median.
Also known as: PA, Physician Associate, Medical Assistant. The estimates on this page are used for these related job titles in San Francisco, CA, although actual pay can differ by title and scope.
Median: BLS OEWS May 2025, Physician Assistants (SOC 29-1071), San Francisco-Oakland-Fremont, CA MSA. Entry, senior and top earner are Salario estimates rescaled to the BLS median.
Physician Assistant Take-Home Pay in San Francisco
Tax Breakdown (Median Salary)
| Gross Annual | $184,380 |
| Federal Tax | -$32,985 |
| State Tax (7.1% eff.) | -$13,055 |
| FICA (SS + Medicare) | -$14,105 |
| Annual Take-Home | $124,234 |
| Monthly Take-Home | $10,353 |
Living Cost Comparison
Physician Assistant Requirements
Key Skills
Physician Assistant salary search terms in San Francisco
People comparing Physician Assistant pay in San Francisco, CA may use related job-title wording. Salario keeps the main estimate tied to the Physician Assistant role, then treats the terms below as comparison phrases that should be checked for licensing, employer type, seniority, and role scope.
| Comparison point | How to use it |
|---|---|
| Primary local answer | $184,380 median salary, $137,900-$235,300 modeled range, and $124,234 estimated take-home pay in San Francisco. |
| Title variants | PA, Physician Associate, Medical Assistant can point to similar searches, but some variants may represent a narrower specialty or a higher/lower seniority band. |
| Offer comparison | Compare base salary, hourly equivalent, take-home pay, certifications, local cost of living, and whether the job is employee, contractor, public-sector, commission-heavy, or management-level. |
San Francisco Job Market Overview
San Francisco, California has a population of 873,965 and an unemployment rate of 3.2%. The top industries are Technology, Finance, Healthcare. The local job growth rate is 2.5%, and the average commute time is 34minutes. These local figures come from Salario's city dataset; verify current values with BLS Local Area Unemployment Statistics and Census QuickFacts.
Related Healthcare Salaries in San Francisco
Physician Assistant Salary in Nearby California Cities
Salary Percentile Breakdown: Physician Assistant in San Francisco
Based on Salario's cost-of-living-adjusted salary tiers for Physician Assistant in San Francisco, CA, here is an estimated percentile breakdown:
| Percentile | Annual Salary | Hourly Equivalent | Career Stage |
|---|---|---|---|
| 10th (lowest) | $137,900 | $66/hr | Entry-level, < 1 yr exp. |
| 25th | $161,140 | $77/hr | Junior, 1-3 yrs exp. |
| 50th (median) | $184,380 | $89/hr | Mid-career, 0-2 years |
| 75th | $235,300 | $113/hr | Senior, 5-10 yrs exp. |
| 90th (top) | $280,300 | $135/hr | Lead/Principal, 10+ yrs |
P50 is the measured BLS OEWS May 2025 metro median; P10, P25, P75 and P90 are approximations, not measured local percentiles: they map to Salario's entry, senior and top tiers rescaled to the BLS median, with P25 interpolated halfway between entry and median. Top earners (P90) typically include managers, specialists with rare skills, or those at high-paying employers in San Francisco's Technology sector.
5-Year Salary Trajectory
Salario's national dataset models approximately 15.0% salary growth for Physician Assistants over the past 5 years. That national assumption is applied to the San Francisco estimate below; it is not a measured local trend, and it should be compared with cumulative CPI inflation before treating it as a real-terms gain:
Year-over-year, an average Physician Assistant can expect a 14.3% annual increase moving from entry to senior level over 4 years in San Francisco. Negotiation, certifications (PANCE, NCCPA Certification), and changing employers strategically can accelerate this trajectory.
San Francisco vs National Average
The national median Physician Assistant salary is $135,880 (BLS OEWS May 2025, Physician Assistants). In the San Francisco-Oakland-Fremont, CA metro, the BLS median of $184,380 is 35.7% above the national figure. San Francisco's cost of living index is 180 (higher than the national average of 100), so the wage premium and the cost premium do not necessarily cancel out.
For Physician Assistants, this means: rent typically consumes 32.8% of take-home pay (households spending >30% are considered rent-burdened), and a median home in San Francisco costs about 10.1× annual take-home. Homeownership in San Francisco on this salary is challenging, most experts recommend keeping home costs to 3-4× income.
Industry Context: Technology in San Francisco
San Francisco's economy is anchored by Technology, Finance, Healthcare, with 873,965 residents and an unemployment rate of 3.2% in Salario's city dataset. Pay for Physician Assistants can differ by sector, so compare Technology employers with other local employers. The local job growth rate in Salario's city dataset is 2.5%, and Salario's job dataset lists a 28.0% growth outlook for Physician Assistant roles; check the BLS Occupational Outlook Handbook for the official 2024-2034 projection for the closest matching occupation.
Methodology & Data Sources
How we calculate Physician Assistant salaries in San Francisco, CA:
- Local median is the BLS OEWS May 2025 median annual wage for Physician Assistants (SOC 29-1071) in the San Francisco-Oakland-Fremont, CA metropolitan statistical area, retrieved from the BLS Public Data API on September 17, 2026. BLS reports by metro area, so this is a regional figure, not a San Francisco-only wage.
- Cost-of-living adjustment is shown only for comparison ($244,584 modeled) using the San Francisco index of 180 relative to the national baseline of 100, with local rent, home price, unemployment, and tax inputs stored separately in Salario's city dataset.
- Percentile distribution (P10-P90) estimated from the entry, median, senior, and top compensation tiers in the Salario salary model rescaled to the BLS metro median rather than claimed as exact employer payroll data.
- Take-home pay calculated using 2026 federal tax brackets (10%-37%), CA 2026 state income tax brackets after the standard deduction (top rate 13.3%), and FICA (Social Security 6.2% + Medicare 1.45%).
- Tax brackets and standard deduction ($16,100 single filer for tax year 2026) sourced from IRS Revenue Procedure 2025-32 and updated annually.
Authoritative data sources:
- BLS Occupational Employment and Wage Statistics, national and metro-area salary data
- O*NET OnLine, occupation tasks, alternate job titles, skills, and SOC crosswalks
- BLS Occupational Outlook Handbook, occupation outlook where a matching profile is available
- BLS Consumer Price Index (CPI-U), regional inflation data (CPI measures price changes, not city-to-city price levels)
- U.S. Census Bureau, San Francisco QuickFacts, population and demographic data
- IRS Revenue Procedure 2025-32 summary, 2026 federal tax brackets and standard deductions
- BLS Local Area Unemployment Statistics, official local unemployment rates to verify the San Francisco figure above
Last reviewed: 2026. Salario's salary dataset is refreshed periodically, not automatically; check the linked BLS releases for the latest official data. Physician Assistant salaries can vary significantly based on employer, sector (Technology vs others in San Francisco), specific skill set (Clinical Examination, Diagnosis, Procedure Assistance), and individual negotiation. Always verify current compensation through multiple sources before making career decisions.
Frequently Asked Questions
What is the average Physician Assistant salary in San Francisco, CA?
How much does a Physician Assistant take home in San Francisco after taxes?
Is San Francisco a good city for Physician Assistants?
What skills are needed for a Physician Assistant in San Francisco?
How does Physician Assistant salary in San Francisco compare to the national average?
What job titles are similar to Physician Assistant in San Francisco?
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Frequently Asked Questions
What is the average Physician Assistant salary in San Francisco, CA?
The median Physician Assistant salary in San Francisco, CA is $184,380 per year: the BLS OEWS May 2025 median annual wage for Physician Assistants (SOC 29-1071) in the San Francisco-Oakland-Fremont, CA metropolitan area. BLS publishes wages by metro area, not by city. The entry-level estimate of around $137,900 and the senior estimate of $235,300 or more are Salario tiers calibrated to that BLS median, not BLS percentiles.
How much does a Physician Assistant take home in San Francisco after taxes?
A Physician Assistant earning the median salary of $184,380 in San Francisco, CA takes home approximately $124,234 per year ($10,353/month) after federal, state, and local taxes. The effective tax rate is 32.6%.
Is San Francisco a good city for Physician Assistants?
San Francisco, CA has a cost of living index of 180 (above national average). Physician Assistants here earn above the city median. The local unemployment rate is 3.2% and top industries include Technology, Finance, Healthcare.
What skills are needed for a Physician Assistant in San Francisco?
Key skills for Physician Assistants include Clinical Examination, Diagnosis, Procedure Assistance, EHR, Patient Education. Typical education requirement is Master's Degree. Valuable certifications include PANCE, NCCPA Certification.
How does Physician Assistant salary in San Francisco compare to the national average?
The national median for Physician Assistants is $135,880 (BLS OEWS May 2025). In the San Francisco-Oakland-Fremont, CA metro, the BLS median is $184,380, which is 35.7% higher than the national figure. For comparison, Salario's cost-of-living model (index 180) would have estimated $244,584.
What job titles are similar to Physician Assistant in San Francisco?
Related search terms for Physician Assistant in San Francisco, CA include PA, Physician Associate, Medical Assistant. Use them as comparison terms, not always exact matches: licensing, employer type, seniority, public-sector rules, and whether the role is W-2, contractor, clinical, technical, management, or sales-focused can change the salary range.